Dystrophic animal models of diaphragm morphology for muscle ultraestructural analysis
نویسندگان
چکیده
T. Borges Lessa*; B. Machado Bertassoli; S. Elisabete Alves de Lima Will; M. Pandolphi Brólio; D. Kelly de Abreu; R. Eli Grassi Rici; M. Angelica Miglino and Carlos E. Ambrósio School of Veterinary Medicine and Animal Science (FMVZ), Surgery Department. Graduate Program in Anatomy of Domestic and Wild Animals, University of Sao Paulo (USP). Av. Prof. Dr. Orlando Marques de Paiva, s/n, CEP 05508270, Sao Paulo, Brazil. College of Animal Science and Food Engineering (FZEA), Veterinary Medicine Department, University of Sao Paulo (USP). Pirassununga, Sao Paulo, Brazil.
منابع مشابه
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Duchenne muscular dystrophy (DMD) is an X-linked recessive disease caused, in most cases, by the complete absence of the 427 kDa cytoskeletal protein, dystrophin. There is no effective treatment, and affected individuals die from respiratory failure and cardiomyopathy by age 30. Here, we investigated whether cardiomyopathy could be prevented in animal models of DMD by increasing diaphragm utrop...
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Duchenne muscular dystrophy (DMD) is a progressive degenerative disease that results in fibrosis and atrophy of muscles. The main cause of death associated with DMD is failure of the diaphragm. The diaphragm is a dome-shaped muscle with a fiber microstructure that differs across regions of the muscle. However, no studies to our knowledge have examined spatial variations of muscle fibers in dyst...
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تاریخ انتشار 2012